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. 2020 Jan 20;2020(1):CD011628. doi: 10.1002/14651858.CD011628.pub2

Matsunami 1990.

Methods Randomised, parallel‐arm study
Number of centres not stated
Period of inclusion not stated
Participants Inclusion criteria

  • Clinical and histological palmoplantar pustulosis according to the characteristics of Baker and Wilkinson


Exclusion criteria
Not stated
Baseline data: participants were randomly divided into 2 groups: Re (+) (n = 10) and Re (‐) (n = 10)

  • Mean age (range) years: 51.7 (43 to 58); 57.8 (36 to 72)

  • Male/female: 4/6; 4/6

  • Mean duration of disease (range) years: 3.9 (0.7 to 14); 4.4 (0.2 to 11)

  • Proportion of participants with psoriatic lesions elsewhere: not specified


Withdrawal: unclear
Interventions Intervention 1
A: etretinate 1 mg/kg for 4 weeks, then 0.5 mg/kg (10 participants)
Intervention 2
B: no treatment (10 participants)
Co‐interventions: PUVA therapy once per week on the right side (for 12 weeks)
Duration of treatment: 12 weeks
Outcomes No primary or secondary outcome pre‐specified
‐ Degree of severity based on various factors with the conclusion of no change, beginning of resolution, or complete clearance
Notes Funding: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "The patients were randomly divided into two groups"
Comment: insufficient information about the sequence generation process to permit judgement
Allocation concealment (selection bias) Unclear risk Comment: no information on method to guarantee allocation concealment
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comment: no mention of blinding and etretinate side effects making blinding impossible
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: no mention of blinding and etretinate side effects making blinding impossible
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: no mention of missing data
Selective reporting (reporting bias) Unclear risk Comment: no protocol found to guarantee that all planned outcomes are presented in the results