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. 2020 Jan 20;2020(1):CD011628. doi: 10.1002/14651858.CD011628.pub2

Murray 1980.

Methods Within‐patient, controlled trial
One centre in London
Period of inclusion not stated
Participants Inclusion criteria
  • Bilaterally symmetrical palmoplantar pustulosis of at least 1 year's duration


Exclusion criteria
Not stated
Participants were seen weekly by a single observer
Baseline data
  • Mean age, years: 47.8 for males and 52.9 for females

  • Male/female: 6/16

  • Duration of disease, years: 5.3

  • Proportion of participants with psoriatic lesions elsewhere: not specified


Withrawal: no dropouts
Interventions Oral 8‐methoxypsoralen (8‐MOP) 2 hours before UVA irradiation (4 times per week) for 30 treatments administered to all 22 participants
Intervention 1
UVA irradiation (22 palms or soles, or both)
Intervention 2
Other side was covered (22 palms or soles, or both)
Duration of treatment: 30 treatments (sessions) (7.5 weeks)
Outcomes No primary or secondary outcome pre‐specified
  • Response using a visual analogue scale (VAS) score

  • Total dose used

Notes Funding: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Patients were irradiated four times per week on one randomly selected side"
Comment: insufficient information about the sequence generation process to permit judgement
Allocation concealment (selection bias) Unclear risk Comment: no information on method to guarantee allocation concealment
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Quote: "The opposite side was covered and served as a control"
Comment: as 1 side was covered, blinding was impossible
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: no mention of blinding
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Quote: "The treated side cleared completely in twelve patients, almost cleared in five patients and improved in four. One patient improved on both sides"
Comment: no missing outcome data
Selective reporting (reporting bias) Unclear risk Comment: no protocol found to guarantee that all planned outcomes are presented in the results