Murray 1980.
Methods | Within‐patient, controlled trial One centre in London Period of inclusion not stated |
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Participants |
Inclusion criteria
Exclusion criteria Not stated Participants were seen weekly by a single observer Baseline data
Withrawal: no dropouts |
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Interventions | Oral 8‐methoxypsoralen (8‐MOP) 2 hours before UVA irradiation (4 times per week) for 30 treatments administered to all 22 participants Intervention 1 UVA irradiation (22 palms or soles, or both) Intervention 2 Other side was covered (22 palms or soles, or both) Duration of treatment: 30 treatments (sessions) (7.5 weeks) |
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Outcomes | No primary or secondary outcome pre‐specified
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Notes | Funding: not reported | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Quote: "Patients were irradiated four times per week on one randomly selected side" Comment: insufficient information about the sequence generation process to permit judgement |
Allocation concealment (selection bias) | Unclear risk | Comment: no information on method to guarantee allocation concealment |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Quote: "The opposite side was covered and served as a control" Comment: as 1 side was covered, blinding was impossible |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Comment: no mention of blinding |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Quote: "The treated side cleared completely in twelve patients, almost cleared in five patients and improved in four. One patient improved on both sides" Comment: no missing outcome data |
Selective reporting (reporting bias) | Unclear risk | Comment: no protocol found to guarantee that all planned outcomes are presented in the results |