Skip to main content
. 2020 Jan 20;2020(1):CD011628. doi: 10.1002/14651858.CD011628.pub2

Rodriguez 2000.

Methods Placebo‐controlled, parallel‐arm study
One centre in Spain
Period of inclusion: June to October 1999
Participants Inclusion criteria

  • Clinical criteria: flares of pustular lesions on palms and/or soles of > 6 months' evolution

  • Pathology criteria: intraepidermal pustules without papillomatosis or other psoriatic changes

  • No response to topical treatment

  • No response to conventional systemic treatment


Exclusion criteria

  • Past history of spontaneous remission of pustular lesions


Baseline data: participants received 20% aqueous solution of aluminium chloride hexahydrate (n = 6) or placebo (n = 6)

  • Mean age, years: 36.5; 34.3

  • Male/female: 4/2; 4/2

  • Mean duration of disease (months): 27.2; 23.7


Withdrawal: no dropouts
Interventions Intervention 1
A: 20% aqueous solution of aluminium chloride hexahydrate (6 participants)
Intervention 2
B: placebo (6 participants)
Co‐interventions: none
Duration of treatment: 5 months
Outcomes No primary or secondary outcome pre‐specified

  • Complete cure (Whitening)

  • Reduction in the number of lesions and itch at 2 months

  • Flare after beginning of treatment

  • Side effects
Notes Funding: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: study authors mentioned that the study is blinded, randomised, and controlled with placebo
Allocation concealment (selection bias) Unclear risk Comment: not clear
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: study authors mention in the methods that the study is blinded, even though in the abstract they say it is an open study
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: study authors mention in the methods that the study is blinded, even though in the abstract they say it is an open study
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: no dropouts
Selective reporting (reporting bias) Unclear risk Comment: no protocol found to guarantee that all planned outcomes are presented in the results