Database	Time span	Search strategy
Central Register of Controlled Trials (CENTRAL) in the Cochrane Library	Issue 7, 2019	#1 (liver or hepatic) #2 (transplant* or graft*) #3 #1 and #2 #4 MeSH descriptor: [Liver Transplantation] explode all trees #5 #3 or #4 #6 immunosuppress* #7 MeSH descriptor: [Immunosuppression] explode all trees #8 MeSH descriptor: [Immunosuppressive Agents] explode all trees #9 #6 or #7 or #8 #10 MeSH descriptor: [Glucocorticoids] explode all trees #11 MeSH descriptor: [Antilymphocyte Serum] explode all trees #12 (corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab) #13 #10 or #11 or #12 #14 #5 and #9 and #13
MEDLINE Ovid	January 1947 to July 2019	1. (liver or hepatic).af. 2. (transplant* or graft*).af. 3. 1 and 2 4. exp Liver Transplantation/ 5. 3 or 4 6. exp Immunosuppression/ or exp Immunosuppressive Agents/ 7. immunosuppress*.ti,ab. 8. 6 or 7 9. exp Glucocorticoids/ 10. exp Antilymphocyte Serum/ 11. (corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab).ti,ab. 12. or/9‐11 13. 5 and 8 and 12 14. randomized controlled trial.pt. 15. controlled clinical trial.pt. 16. randomized.ab. 17. placebo.ab. 18. drug therapy.fs. 19. randomly.ab. 20. trial.ab. 21. groups.ab. 22. 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 23. exp animals/ not humans.sh. 24. 22 not 23 25. 13 and 24
Embase Ovid	January 1974 to July 2019	1. (liver or hepatic).af. 2. (transplant* or graft*).af. 3. 1 and 2 4. exp liver transplantation/ 5. 3 or 4 6. exp immunosuppressive treatment/ or exp immunosuppressive agent/ 7. immunosuppress*.ti,ab. 8. 6 or 7 9. exp glucocorticoid/ 10. exp thymocyte antibody/ 11. (corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab).ti,ab. 12. or/9‐11 13. 5 and 8 and 12 14. exp crossover‐procedure/ or exp double‐blind procedure/ or exp randomized controlled trial/ or single‐blind procedure/ 15. (((((random* or factorial* or crossover* or cross over* or cross‐over* or placebo* or double*) adj blind*) or single*) adj blind*) or assign* or allocat* or volunteer*).af. 16. 14 or 15 17. 13 and 16
Science Citation Index Expanded (Web of Science)	January 1945 to July 2019	#1 TS=((liver or hepatic) AND (transplant* or graft*)) #2 TS=(immunosuppress*) #3 TS=(corticosteroids or glucocorticoids or prednisolone or prednisone or methylprednisolone or cortisol or cortisone or methylprednisolone or betamethasone or thymoglobulin or antithymocyte or antilymphocyte or anti‐thymocyte or thymocyte antibody or anti‐lymphocyte or alemtuzumab or basiliximab or daclizumab) #4 TS=(random* OR rct* OR crossover OR masked OR blind* OR placebo* OR meta‐analysis OR systematic review* OR meta‐analys*) #5 #1 and #2 and #3 and #4
World Health Organization International Clinical Trials Registry Platform (apps.who.int/trialsearch/Default.aspx)	July 2019	liver transplant* AND immunosuppress*
ClinicalTrials.gov	July 2019	Interventional Studies | liver transplant* | immunosuppression | Phase 2, 3, 4
European Medicines Agency (www.ema.europa.eu/ema/) and US Food and Drug Administration (www.fda.gov)	July 2019	liver transplant