Babaei 2018.

Methods	Randomised controlled trial
Participants	Sixty‐nine neonates with PMA < 34 weeks and postnatal age < 14 days with significant PDA (confirmed through echocardiography), who had contraindications for ibuprofen and indomethacin were recruited
Interventions	The paracetamol group (n = 36) received oral paracetamol at a dose of 15 mg/kg/dose every 6 hours for 72 hours. The control group (n = 33) did not receive any intervention. After 72 hours, both groups were re‐evaluated by echocardiography. In case of failed closure of the PDA, the second course of treatment with paracetamol was administrated
Outcomes	Primary outcome: the rate of closure of PDA Secondary outcomes: the side effects of acetaminophen
Notes	This study was published on February 28, 2018, after our review had been submitted to the Cochrane Neonatal Editorial Office. The results will be included in the next update of the review