NCT02056223.

Trial name or title	Paracetamol versus ibuprofen for PDA closure in preterm infants. (PARIDA)
Methods	A prospective, randomised, controlled, double‐blind, multicenter clinical trial.
Participants	Preterm neonates ≤ 31 + 6 days weeks' PMA with HsPDA
Interventions	Group A: experimental boluses of paracetamol at 15 mg/kg 4 times a day for 3 consecutive days. Group B: standard boluses of ibuprofen at 10 ‐ 5 ‐ 5 ‐ mg/kg/dose once a day for 3 consecutive days.
Outcomes	The rate of ductal closure after the first and second course of pharmacological treatment. (PDA diagnosed by ECHO criteria) in paracetamol versus ibuprofen group. Oliguria, IVH, NEC
Starting date	9 January 2017
Contact information	Contact: Paola Lago, MD; Sabrina Salvadori, MD
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