NCT03265782.

Trial name or title	Comparison between the effect of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus in preterm and low birth weight infants
Methods	Randomised open label trial with parallel assignment
Participants	PMA ≤ 35 weeks, age 2 to 7 days with colour Doppler echocardiographic evidence of PDA, urine output more than 1 mL/kg/h and creatinine concentration level less than 1.8 mg/dl
Interventions	Ibuprofen administered with a loading dose of 10 mg/kg/day followed by 5 mg/kg/day in 2 doses with 24 h apart for 3 days Paracetamol drug administered for 3 consecutive days in a dose of 15 mg/kg/dose every 6 h
Outcomes	Echo‐confirmed closure of PDA (time frame: 6 days)
Starting date	June 2015
Contact information	Rania Ali El‐Farrash, Ain Shams University, Cairo, Egypt
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