Comparison 1. Lactase treatment versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Weight gain (grams/day) on day 7 after study entry	1	130	Mean Difference (IV, Fixed, 95% CI)	4.50 [‐0.76, 9.76]
2 Weight gain (grams/day) on day 10 after study entry	1	130	Mean Difference (IV, Fixed, 95% CI)	4.90 [0.18, 9.62]
3 Weight gain (grams/day) on day 14 after study entry or at study exit (if this occurred earlier)	1	130	Mean Difference (IV, Fixed, 95% CI)	2.70 [‐1.47, 6.87]
4 Weight gain (grams/day) on study exit	1	130	Mean Difference (IV, Fixed, 95% CI)	2.20 [‐0.98, 5.38]
5 Length gain (cm/week) on day 14 after study entry or at study exit (if this occurred earlier)	1	130	Mean Difference (IV, Fixed, 95% CI)	0.30 [‐0.13, 0.73]
6 Head circumference gain (cm/week) on day 14 after study entry or at study exit (if this occurred earlier)	1	130	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐0.18, 0.38]
7 Feeding intolerance (not specified)	1	130	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.19, 2.18]
8 Necrotizing enterocolitis	1	130	Risk Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.79]
9 Number of infants with at least one episode of emesis during the study period	1	130	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.80, 1.13]
10 Serum albumin (grams/L) on study day 14 or at study exit if this occurred earlier	1	130	Mean Difference (IV, Fixed, 95% CI)	2.20 [0.78, 3.62]