Each action potential model has different advantages and disadvantages, with numerous results being model specific.
The etiology of AF is diverse, but currently available cardiomyocyte models only have limited options for tailoring models to specific clinical conditions.
Only a handful of labs worldwide have the available expertise, computing power and required collaboration between clinicians, scientists and engineers to apply mechanistic whole-atria models in the clinical setting.
The extent of personalization of whole-atria models, particularly with regard to electrophysiological properties, remains very limited.
Current patient-level models do not incorporate fundamental mechanistic patterns of AF pathophysiology.
Integration of mechanistic modeling with “big data” approaches might help to improve AF diagnosis and management.
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