Table 3.
The information of the top 10 key targets with the active ingredient number exceeding 14.
| Gene | UniProt ID | Description | Active ingredients |
|---|---|---|---|
| PTGS2 | P35354 | Prostaglandin G/H synthase 2 | 74 kinds, beta-sitosterol, quercetin, berberine, etc. |
| ESR1 | P03372 | Estrogen receptor | 59 kinds, beta-sitosterol, quercetin, berberine, etc. |
| NOS2 | P35228 | Nitric oxide synthase, inducible | 37 kinds, beta-sitosterol, quercetin, berberine, etc. |
| NR3C1 | P04150 | Glucocorticoid receptor | 29 kinds, formononetin, coptisine, baicalein, etc. |
| HSD11B1 | P28845 | 11-Beta-hydroxysteroid dehydrogenase 1 | 28 kinds, stigmasterol, daucosterol, delta 7-stigmastenol, etc. |
| PPARA | Q07869 | Peroxisome proliferator-activated receptor alpha | 21 kinds, formononetin, coniferin, delta 7-stigmastenol, etc. |
| HSD11B2 | P80365 | 11-Beta-hydroxysteroid dehydrogenase 2 | 19 kinds, hederagenin, bidentatoside, mandenol, etc. |
| NR3C2 | P08235 | Mineralocorticoid receptor | 19 kinds, wallichilide, epiberberine, methyl oleate, etc. |
| DPP4 | P27487 | Dipeptidyl peptidase IV | 14 kinds, baicalein, quercetin, methyl oleate, etc. |
| NOS3 | P29474 | Nitric-oxide synthase, endothelial | 14 kinds, isorhamnetin, coptisine, syringin, etc. |