Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The RNA-binding protein ELAVL1 regulates ferroptosis by inducing ferritinophagy activation in HSCs. Ferroptosis-inducing compounds increase ELAVL1 expression through the inhibition of the ubiquitin-proteasome pathway. Increased ELAVL1 can bind to the AREs of the BECN1 mRNA 3ʹ-UTR, trigger autophagy activation, promote autophagic ferritin degradation, and in turn, lead to HSC ferroptosis.
