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. 2018 Sep 14;14(12):2049–2064. doi: 10.1080/15548627.2018.1495681

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — LC-MS/MS analysis reveals differentially expressed proteins in BMD macrophages treated with DEX or CpdA under the inflammatory condition. (A) Schematic overview of the mass spectrometry-based shotgun proteomics experiment. (B) Volcano plot with significantly up- (red) or downregulated (green) proteins in CpdA + LPS versus LPS alone. CpdA (10 μM) and 100 ng/ml LPS treatments were used. Statistics by multiple two-sample t-tests, each with a permutation-based FDR of 0.05 and S0 value of 0.1 for truncation. (N = 3). (C) Ingenuity pathway analysis (www.qiagenbioinformatics.com) of significantly regulated proteins from CpdA+ LPS versus LPS comparison. (D) Volcano plot with significantly up- (red) or downregulated (green) proteins in DEX + LPS versus LPS. DEX (1 μM) and 100 ng/ml LPS treatments were used. Statistics by multiple two-sample t-tests, each with a permutation-based FDR of 0.05 and S0 value of 0.1 for truncation. (N = 3). (E) Ingenuity pathway analysis of significantly regulated proteins from DEX+ LPS versus LPS comparison.