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. 2019 Dec 27;45(2):543–555. doi: 10.3892/ijmm.2019.4443

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miR-146a regulates glucose metabolism in the liver of high-fat diet mice. (A) The relative miR-146a expression level in the liver of HFD mice infected with Ad-miR-146a mimic or Ad-NC (n=6). (B) The fasting glucose level of serum in HFD mice infected with Ad-miR-146a mimic or Ad-NC (n=6). (C-F) Glucose tolerance test (C) and insulin tolerance test (E) analysis of HFD mice infected with Ad-miR-146a mimic or Ad-NC. The area under the curve (AUC) of GTT (D) and ITT (F) were calculated (n=6). (G) Glycogen content analysis in the livers of HFD mice infected with Ad-miR-146a mimic or Ad-NC (n=6). (H) Serum insulin levels in HFD mice infected with Ad-NC or Ad-miR-146a mimic (n=6). (I) The expression levels of gluconeogenic genes (PEPCK, G6Pase and PGC1a) in the livers of HFD mice infected with Ad-miR-146a mimic or Ad-NC. Means ± SD are shown. ^*P<0.05; ^**P<0.01; ^***P<0.001.