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Endogenous GLP-1 is not protective in COPD. Data are presented as time-effects plots from day 12 to 21 in the left panel. Right panel shows bar graphs at day 18, 12 hours after the last LPS inhalation. A, Study investigating the effect on PenH by antagonizing the GLP-1R with EX-9, n = 48. B, GLP-1R KO and WT, n = 30. Data are shown as means ± SEM. Statistics were carried out with 1-way ANOVA followed by Bonferroni post hoc test. **P < .01
