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. 2019 Dec 30;45(2):298–314. doi: 10.3892/ijmm.2019.4449

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Copyright: © Flüh et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Double immunostaining of dormancy markers. Selected images from different cerebral metastases of lung and breast cancer. (A) Double immunos-taining for 'central' dormancy markers EphA5, H2BK and IGFBP5 in representative cryosections from cerebral metastases of breast (left column) and lung cancer (right column). (B) Double immunostaining for 'peripheral' dormancy markers PDGFβ, FGF2 and HIF1-α in exemplary cryosections from cerebral metastases of breast (left column) and lung cancer (right column). (C) Double immunostaining for 'central' with 'peripheral' dormancy markers in exemplary cryosections from cerebral metastases of breast (left column) and lung cancer (right column). Scale bar=20 µm. The images in the white boxes show another representative image in the same tumor. H2BK, Histone cluster 1 H2B family member K; IGFBP5, insulin-like growth factor-binding protein 5; EphA5, Ephrin receptor A5; FGF2, fibroblast growth factor 2; PDGFβ, platelet-derived growth factor β; HIF1-α, hypoxia-inducible factor 1-α.

Double immunostaining of dormancy markers. Selected images from different cerebral metastases of lung and breast cancer. (A) Double immunos-taining for 'central' dormancy markers EphA5, H2BK and IGFBP5 in representative cryosections from cerebral metastases of breast (left column) and lung cancer (right column). (B) Double immunostaining for 'peripheral' dormancy markers PDGFβ, FGF2 and HIF1-α in exemplary cryosections from cerebral metastases of breast (left column) and lung cancer (right column). (C) Double immunostaining for 'central' with 'peripheral' dormancy markers in exemplary cryosections from cerebral metastases of breast (left column) and lung cancer (right column). Scale bar=20 µm. The images in the white boxes show another representative image in the same tumor. H2BK, Histone cluster 1 H2B family member K; IGFBP5, insulin-like growth factor-binding protein 5; EphA5, Ephrin receptor A5; FGF2, fibroblast growth factor 2; PDGFβ, platelet-derived growth factor β; HIF1-α, hypoxia-inducible factor 1-α.