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. 2019 Dec 6;45(2):429–440. doi: 10.3892/ijmm.2019.4420

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Immunohistochemistry analysis of S1PR1, STAT3 and p-STAT3 in valve tissues. (A) Immunohistochemistry for S1PR1, STAT3 and p-STAT3 in valve tissues; magnification, ×400; the arrows represent positive cells. (B) The IHS. (C) The positive cells percentage. This figure shows that expression of S1PR1 was increased and expression of p-STAT3 was decreased after AAV-injection. (D) The ratio of phosphorylated vs. total protein for STAT3 (ISH score). (E) The ratio of phosphorylated vs. total protein for STAT3 (positive cells percentage). Data are shown as the mean ± standard deviation; ^*P<0.05 vs. the control group. ^#P<0.05 vs. the RHD group. S1PR1, sphingosine-1-phosphate receptor 1; t-STAT3, total-signal transducer and activator of transcription 3; p-STAT3, phosphorylated STAT3; IHS, immunohistochemical score; RHD, rheumatic heart disease.