Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 4;45(2):279–297. doi: 10.3892/ijmm.2019.4418

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Katoh et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Genetic alterations in the Notch signaling components in human cancers. Notch signaling cascades are aberrantly activated in solid tumors and hema-tological malignancies owing to overexpression of Notch receptors and GoF mutations or fusions in the NOTCH family genes. By contrast, Notch signaling cascades are inactivated in small-cell lung cancer and squamous cell carcinomas owing to LoF mutations in the NOTCH family genes, especially NOTCH1. NECD, Notch extracellular domain; NRR, Notch negative regulatory region; NTMD, Notch transmembrane domain; PEST, proline-, glutamate-, serine- and threonine-rich domain that undergoes FBXW7-mediated ubiquitylation; UP, upregulation; GoF, gain-of-function; LoF, loss-of-function; SEC16A, protein transport protein Sec16A; TCRB, T cell receptor β locus; PARS2, prolyl-tRNA synthetase 2, mitochondrial; SEC22B, vesicle-trafficking protein SEC22b.