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. 2020 Jan 22;7(1):ENEURO.0315-19.2019. doi: 10.1523/ENEURO.0315-19.2019

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Copyright © 2020 Johnson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Photostimulation of ChR2 in β-End terminals in the MPN internalizes the MOR. Photostimulation induced the internalization of MOR within cells in the MPN. A, A one-way ANOVA indicated that there was a significant difference in receptor internalization between groups (F_(2,11) = 5.15, p = 0.03, r ² = 0.48). Tukey’s multiple comparisons test indicated that mice with ChR2 in β-End terminals in the MPN showed a greater percentage of the area of the image covered by MOR-ir (mean, 8.7 ± 1.8%) as compared to both mice that received the control AAV (mean, 4.3 ± 0.4%; *p = 0.05) and those with ChR2 but incorrect fiber optic placement (mean, 3.7 ± 0.4%, **p = 0.04). Images show DAPI (blue) and MOR (green) in a representative cell from group 1 (B) and group 2 (C). Scale bar = 2 µm. All values expressed as mean ± SEM.