Table 2:
Various measures of resistance overall and stratified by VL groupa.
| Resistance Measure | Total (n=105; 48/105 visit 2) | 40 < VL ≤ 1000 (n=35; 17/35 visit 2) | VL > 1000 (n=70; 31/70 visit 2) | VL ≤ 1000 vs VL > 1000 Effect (95%, CI) |
|---|---|---|---|---|
| Resistance category (visit 1) | Fisher Exact Test p=0.31 | |||
| None | 22, 21% | 7, 20% | 15, 21% | |
| NRTI Only | 3, 3% | 0, 0% | 3, 4% | |
| NNRTI Only | 13, 12% | 3, 9% | 10, 14% | |
| NRTI/NNRTI Only | 58, 55% | 23, 66% | 35, 50% | |
| PI | 9, 9% | 2, 6% | 7, 10% | |
| # drug classes with resistance (visit 1) | Fisher Exact Test p=0.56 | |||
| 0 | 22, 21% | 7, 20% | 15, 21% | |
| 1 | 16, 15% | 3, 9% | 13, 19% | |
| 2 | 60, 57% | 24, 69% | 36, 51% | |
| 3 | 7, 7% | 1, 3% | 6, 9% | |
| NRTI/NNRTI/PI Resistanceb | ||||
| Any, visit 1 | 83, 79% | 28, 80% | 55, 79% | OR = 1.09 (0.40, 2.98) |
| Any accumulation | 19, 40% | 8, 47% | 11, 35% | AOR = 1.59 (0.45, 5.59) |
| # of mutations, visit 1 | 3.53 (0, 13) | 4.57 (0, 13) | 3.01 (0, 11) | RR = 1.52 (1.23, 1.86) |
| # of accumulated mutations | 0.92 (0, 5) | 1.41 (0, 5) | 0.65 (0, 4) | ARR = 2.48 (1.34, 4.58) |
| NRTI Resistanceb | ||||
| Any, visit 1 | 70, 67% | 25, 71% | 45, 64% | OR = 1.39 (0.58, 3.35) |
| Any accumulation | 10, 21% | 5, 29% | 5, 16% | AOR = 3.81 (0.69, 21.02) |
| # of mutations, visit 1 | 2.04 (0, 9) | 3.03 (0, 9) | 1.54 (0, 6) | RR = 1.96 (1.50, 2.57) |
| # of accumulated mutations | 0.44 (0, 4) | 0.76 (0, 4) | 0.26 (0, 2) | ARR = 4.18 (1.72, 10.16) |
| NNRTI Resistanceb | ||||
| Any, visit 1 | 78, 74% | 27, 77% | 51, 73% | OR = 1.26 (0.49, 3.25) |
| Any accumulation | 16, 33% | 7, 41% | 9, 29% | AOR = 1.57 (0.43, 5.72) |
| # of mutations, visit 1 | 1.28 (0, 4) | 1.37 (0, 4) | 1.23 (0, 4) | RR = 1.12 (0.78, 1.59) |
| # of accumulated mutations | 0.4 (0, 2) | 0.47 (0, 2) | 0.35 (0, 2) | ARR = 1.39 (0.54, 3.57) |
| Major PI Resistanceb | ||||
| Any, visit 1 | 9, 9% | 2, 6% | 7, 10% | OR = 0.55 (0.11, 2.78) |
| Any accumulation | 2, 4% | 1, 6% | 1, 3% | AOR = 1.56 (0.09, 26.8) |
| # of mutations, visit 1 | 0.22 (0, 4) | 0.17 (0, 4) | 0.24 (0, 4) | RR = 0.71 (0.28, 1.79) |
| # of accumulated mutations | 0.08 (0, 3) | 0.18 (0, 3) | 0.03 (0, 1) | ARR = 4.59 (0.48, 44.11) |
| Resistance to Current Medicationsc | ||||
| Any, visit 1 | 65, 62% | 25, 71% | 40, 57% | OR = 1.39 (0.58, 3.35) |
| Any, visit 2 | 29, 60% | 14, 82% | 15, 48% | AOR = 6.55 (0.83, 52.06) |
| # with resistance, visit 1 | 1.19 (0, 4) | 1.43 (0, 3) | 1.07 (0, 4) | Δ = 0.36 (−0.08, 0.80) |
| # resistance, visit 2 | 1.23 (0, 4) | 1.65 (0, 3) | 1.00 (0, 4) | Δ = 0.65 (0.00, 1.29) |
| Resistance to Future Medicationsc | ||||
| Any, visit 1 | 65, 62% | 24, 69% | 41, 59% | OR = 1.54 (0.65, 3.64) |
| Any, visit 2 | 29, 60% | 12, 71% | 17, 55% | AOR = 2.23 (0.45, 11.05) |
| # with resistance, visit 1 | 1.44 (0, 5) | 1.83 (0, 5) | 1.24 (0, 5) | Δ = 0.59 (−0.03, 1.21) |
| # resistance, visit 2 | 1.48 (0, 4) | 1.65 (0, 4) | 1.39 (0, 4) | Δ = 0.26 (−0.68, 1.2) |
Measures presented as mean (range) for continuous and n, % for categorical measures.
Resistance: OR = Odds Ratio from unadjusted logistic regression; RR = Rate Ratio from unadjusted Poisson Regression; ARR = Rate Ratio from Poisson Regression, adjusted for the number of mutations at visit 1; AOR = Odds Ratio from logistic regression adjusted for presence of resistance at visit 1.;
Medications: Δ = difference from t-test; OR = Odds Ratio from unadjusted logistic regression; AOR = Odds Ratio from logistic regression adjusted for presence of resistance to medications at visit 1. Abbreviations: #, number; NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; PI, protease inhibitor.