Table 2.

Heritability estimates of Pro-C3 and other ECM remodeling biomarkers in AE model

Trait	Heritability estimates h2	95% CI	P value
Primary outcome
Pro-C3 (ng/mL)
Unadjusted	0.373	(0.097–0.592)	0.0089
Age-sex-adjusted	0.336	(0.051–0.567)	0.0215
Age-sex-ethnicity-BMI-adjusted	0.362	(0.072–0.585)	0.0157
Secondary outcome
P4NP7S (ng/mL)
unadjusted	0.136	(0.000–0.337)	0.460
Age-sex- adjusted	0.119	(0.000–0.322)	0.279
Age-sex-ethnicity-BMI-adjusted	0.078	(0.000–0.289)	0.488
PRO-C6 (ng/mL)
unadjusted	0.256	(0.005–0.476)	0.0449
Age-sex- adjusted	0.241	(0.000–0.463)	0.0605
Age-sex-ethnicity-BMI-adjusted	0.075	(0.000–0.327)	0.572
C3M (ng/mL)
unadjusted	0.126	(0.000–0.324)	0.235
Age-sex- adjusted	0.117	(0.000–0.316)	0.272
Age-sex-ethnicity-BMI-adjusted	0.082	(0.000–0.287)	0.453
C4M2 (ng/mL)
unadjusted	0.087	(0.000–0.313)	0.472
Age-sex- adjusted	0.043	(NA −0.278)	0.7297
Age-sex-ethnicity-BMI-adjusted	0	(NA −0.23)	1
Pro-C5 (ng/mL)
unadjusted	0.048	(NA −0.282)	0.6996
Age-sex- adjusted	0.019	(NA −0.258)	0.8816
Age-sex-ethnicity-BMI-adjusted	0	(NA −0.212)	1