. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Hepatology. 2019 Apr 29;70(1):127–141. doi: 10.1002/hep.30610

Table 3.

AE Model for genetic and environmental correlation between Pro-C3 concentration and hepatic steatosis and fibrosis

Pro-C3 (ng/mL)	Genetic correlation
	Hepatic steatosis (MRI-PDFF)		Liver fibrosis (MRE)
	r_G Estimate(95% CI)	P value	r_G Estimate(95% CI)	P value
unadjusted	0.593 (0.240, 1.000)	0.00109	0.245 (−0.332, 0.580)	0.303
Age - sex-adjusted	0.671 (0.302, 1.000)	0.00041	0.301 (NA, 0.680)	0.320
Age-sex-ethnicity-BMI-adjusted	0.619 (0.236, 1.000)	0.00152	0.227 (−1.000, 0.830)	0.596
Pro-C3 (ng/mL)	Environmental correlation
	Hepatic steatosis (MRI-PDFF)		Liver fibrosis (MRE)
	r_E Estimate(95% CI)	P value	r_E Estimate(95% CI)	P value
unadjusted	−0.210 (−0.451, 0.066)	0.132	0.528 (0.291, 0.702)	<0.001
Age – sex-adjusted	−0.217 (−0.457, 0.059)	0.121	0.519 (0.281, 0.695)	<0.001
Age-sex-ethnicity-BMI-adjusted	−0.231 (−0.470, 0.045)	0.0982	0.549 (0.317, 0.717)	<0.001