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. 2020 Jan 27;22(2):34. doi: 10.1208/s12248-020-0417-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Medium types recommended for in vivo predictive dissolution measurements. For pK_a ≤ 7 (acids) and pK_a ≥ 5.5 (bases), three different options are provided to accommodate different dissolution testing goals. BS/PL, bile salts and phospholipids; log D, logarithm of the pH-adjusted partition coefficient between octanol and water. α, pK_a-log S_o; β, pK_w-pK_a-log S_o. All buffers should be adjusted to an ionic strength of 0.15 M