. 2020 Jan 27;22(2):34. doi: 10.1208/s12248-020-0417-8

Table II.

Effect of Interplay Between BDM and Drug-Substance Properties on Dissolution

BDM property	Drug-substance property	Effect of BDM-drug-substance interplay
pH	• pK_a^a	Extent of drug ionization across pH range of GI tract
pH	• Acid/base character	Extent of drug ionization across pH range of GI tract
Buffer capacity	• pK_a	Extent of surface pH alteration by charged drug species
	• Acid/base character
	• Intrinsic solubility
Concentration of bile salts and phospholipids	• Log P^b/log D^c	Extent of drug solubilization in mixed lipidic aggregates

pK_a, negative log of the acid dissociation constant (K_a); log P, logarithm of the partition coefficient between octanol and water for a completely non-ionized molecule; log D, logarithm of the pH-adjusted partition coefficient of a molecule between octanol and water