Table 3.
Association of MMR status with biomarkers
| Parameters | MMR loss n = 31 |
MMR intact n = 1604 |
p value |
|---|---|---|---|
| ER | N.S. | ||
| Negative | 9 | 478 | |
| Positive | 22 | 1125 | |
| Unknown | 1 | ||
| PR | 0.004 | ||
| Negative (< 1%) | 21 | 718 | |
| Positive (≥ 1%) | 7 | 825 | |
| Unknown | 3 | 61 | |
| Her2 (erbb2) | N.S. | ||
| Negative | 25 | 1325 | |
| Positive | 5 | 248 | |
| Unknown | 1 | 31 | |
| Krt5/6 (CK5/6) | N.S. | ||
| Negative | 22 | 1308 | |
| Positive | 4 | 160 | |
| Unknown | 5 | 136 | |
| EGFR | N.S. | ||
| Negative | 26 | 1233 | |
| Positive | 2 | 250 | |
| Unknown | 3 | 121 | |
| Ki67 | N.S. | ||
| Negative (< 14%) | 12 | 754 | |
| Positive (≥ 14%) | 15 | 764 | |
| Unknown | 4 | 86 | |
| Subtypes | |||
| Luminal A | 10 | 616 | N.S. |
| Luminal B | 12 | 494 | |
| HER2E | 2 | 134 | |
| Triple negative/basal | 4 | 275 | |
| Indeterminate | 3 | 85 | |
| PD-1 | |||
| Intra-epithelial TIL | N.S. | ||
| 0 | 28 | 1357 | |
| ≥ 1% | 2 | 184 | |
| Unknown | 1 | 63 | |
| PD-L1 | |||
| Negative (< 1%) | 20 | 1356 | 0.059 |
| Positive (≥ 1%) | 6 | 165 | |
| Unknown | 5 | 83 | |
| H&E sTILs count (%) | |||
| Median | 5 | 1 | 0.009a |
| Interquartile range | 1–10 | 1–5 | |
| Unknown | 3 | 97 | |
N.S. not significant (p value > 0.05)
aMann–Whitney test