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NGT16 harbors HIST1H3B K27M and ACVR1 mutations. (A) NGT16 cell line grows as adherent monolayer in culture. (B) HIST1H3B K27M mutation was confirmed in NGT16. (C) H3F3A K27M mutations were verified in SF7761, SF8628, and JHH-DIPG1 cell lines. (D) ACVR1 G328E mutation was also detected in NGT16, confirming that mutations found in the primary tumor were preserved in the cell line. (E) Downstream activation of the BMP pathway was observed in NGT16 and SF8628 cell lines, but not SF7761.
