Fig. 2.

Expressional and mutational landscape of YARS in gastric cancer datasets. a The landscape of YARS expression, EGFR amplification, 26 other mutations, as well as the mutation burdens across gastric cancer TCGA-GC and MS datasets were displayed. b For TCGA-GC and MS datasets, relative expressions of YARS in EGFR-nonamplified (EGFR-nonAMP) and EGFR-amplified (EGFR-AMP) groups were compared. c Changes of YARS and EGFR in HGC-27/AGS cells after overexpressing YARS or EGFR were assessed by western blot. d For TCGA-GC and MS datasets, relative expressions of YARS among different molecular subtypes (MSS/MSI-L/MSI-H, or GS/CIN/EBV/MSI) were compared. e For TCGA-GC and MS datasets, the mutual correlation between YARS expression and TMB was compared with Pearson’s correlation analysis. *p < 0.05