Fig. 6.

YARS promoted homologous recombination and insensitized responses to PARP inhibitors in gastric cancer. For HGC-27/AGS cells, changes of the homologous recombination pathway representative components (ATM, BRCA1, MRE11, 53BP1, RAD51) after a YARS depletion or b YARS overexpression were assessed by western blot. After YARS depletion in GC cells, 48 h responses to the concentration cascades of c three chemotherapy agents (cisplatin, 5-FU, paclitaxel) or d two PARP inhibitors (Olaparib, Niraparib) were assessed with CCK-8 assay. v vector, Y YARS. *p < 0.05. ns not significant