Fig. 7.

YARS augmented proliferation, invasiveness, and homologous recombination in gastric cancer through activating PI3K-Akt signaling. For YARS-overexpressed HGC-27/AGS cells, a changes of the PI3K-Akt pathway representative members (p-S6, S6, p-Akt, Akt), the homologous recombination pathway representative components (BRCA1, 53BP1, RAD51) and YARS; b changes of cell proliferation, as well as c, d changes of migration/invasion after BEZ235 administration were assessed, while e the 48 h responses to Olaparib combining BEZ235 were assessed with CCK-8 assay. v vector, Y YARS. *p < 0.05. ns not significant