Table 2.
Pharmacokinetic parameter of SeC in mouse.
| Parameter | CysSe2 (5 mg/kg) |
MeSeA (5 mg/kg) |
Ebselen (2 mg/kg) |
p-XSC (2 mg/kg) |
|---|---|---|---|---|
| AUC (µg/mL·h) | 4.1 ± 1.1 | N.A. | 5.7 ± 0.7 | 10.8 ± 2.4 |
| Cmax (µg/mL) | 20.4 ± 2.7 | N.A. | 18.1 ± 3. 7 | 14.8 ± 2.7 |
| Cl (mL/h) | 38.5 ± 11.7 | N.A. | 10.6 ± 1.3 | 5.8 ± 1.3 |
| K10-HL (min) | 8.4 ± 1.2 | N.A. | 13.2 ± 2.4 | 30.6 ± 7.2 |
| MRT (min) | 12 ± 2.4 | N.A. | 19.2 ± 3.6 | 44.4 ± 10.2 |
| Vss (mL) | 7.5 ± 1.0 | N.A. | 3.4 ± 0.6 | 4.1 ± 0.8 |
SeC concentration-time curve was fitted into one-compartment open model to calculate pharmacokinetic parameters. Results are shown as mean ± SD of three mice per compound. N.A. refers to not available. AUC: area under the curve; Cmax: peak concentration; Cl: rate of clearance; K10-HL: elimination half-life; MRT: mean retention time; Vss: apparent volume of distribution at steady state. N.A. refers to not available.