Table 4.

The occurrence of adverse events

Adverse events	Apatinib combined therapy N = 12		Chemotherapy N = 12		P
	Type I-II	Type III-IV	Type I-II	Type III-IV
hand-foot skin reaction	4(33.3%)	1(8.3%)	1(8.3%)	0	0.624
Hypertension	3(25.0%)	2(16.7%)	0	0
Myelosuppression	2(9.1%)	0	3(25.0%)	1(8.3%)	0.350
proteinuria	1(8.3%)	1(8.3%)	0	0
Oral mucosal ulcer	2(9.1%)	0	1(8.3%)	0
Fatigue	4(33.3%)	1(8.3%)	2(16.7%)	1(8.3%)	0.673
Diarrhea	1(8.3%)	0	1(8.3%)	0
Total case number	15	5	8	2	0.760