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. 2020 Jan 27;11:532. doi: 10.1038/s41467-020-14381-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a In the Biopsy Trifecta EXTraction (BioTEXT) protocol, patient derived OCT-embedded core needlebiopsies are sectioned, followed up by extraction of DNA, RNA and proteins for deep-scale proteogenomics characterization and by immunohistochemistry-based imaging. b The Microscaled Proteomics (MiProt) workflow allows deep-scale proteomics and phosphoproteomics characterization with 25 μg of peptides per core-needle biopsy. MiProt uses a common reference that could be used for comparison across all samples within a single-TMT10/11 plex and across several TMT10/11 plexes spanning several core biopsies.