Table 3.
The maximum difference of EARs in organs obtained from different groups after the setup error simulations for all alternative techniques in breast cancer patients, and the data was based on the full mechanistic dose-response model.
| Organs | Index | W-TF | 2F-IMRT | 6F-IMRT | VMAT | ||||
|---|---|---|---|---|---|---|---|---|---|
| Max Difference | P | Max Difference | P | Max Difference | P | Max Difference | P | ||
| CB | G1 | 3.944 ± 1.893 | >0.05 | 78.935 ± 29.664 | <0.05 | 83.168 ± 26.839 | <0.001 | 73.624 ± 15.009 | <0.05 |
| G2 | 1.559 ± 0.489 | >0.05 | 22.750 ± 5.990 | <0.001 | 25.485 ± 8.184 | <0.001 | 28.810 ± 10.254 | <0.05 | |
| G3 | 1.253 ± 0.596 | >0.05 | 9.858 ± 12.338 | >0.05 | 12.089 ± 6.744 | >0.05 | 19.067 ± 8.024 | <0.05 | |
| CL | G1 | 0.690 ± 0.293 | >0.05 | 3.067 ± 2.264 | >0.05 | 6.075 ± 2.635 | >0.05 | 15.178 ± 9.002 | >0.05 |
| G2 | 0.461 ± 0.204 | >0.05 | 2.102 ± 1.894 | >0.05 | 3.768 ± 2.328 | >0.05 | 8.514 ± 3.038 | >0.05 | |
| G3 | 0.343 ± 0.149 | >0.05 | 0.893 ± 0.742 | >0.05 | 2.341 ± 1.689 | >0.05 | 10.267 ± 8.870 | >0.05 | |
| IL | G1 | 13.513 ± 6.388 | >0.05 | 351.480 ± 149.585 | <0.05 | 290.865 ± 28.100 | <0.05 | 290.035 ± 30.123 | <0.05 |
| G2 | 5.084 ± 1.758 | >0.05 | 287.046 ± 26.887 | <0.05 | 283.481 ± 29.098 | <0.05 | 289.754 ± 22.273 | <0.05 | |
| G3 | 3.281 ± 2.198 | >0.05 | 297.112 ± 61.753 | <0.05 | 297.658 ± 51.001 | <0.05 | 291.812 ± 50.111 | <0.05 | |
Note: EAR = excess absolute risk. CB = contralateral breast, CL = contralateral lung and IL = ipsilateral lung. W-TF = 3D-CRT with two tangential fields and wedges, 2F-IMRT = IMRT with two tangential fields, 6F-IMRT = IMRT with six fields, and VMAT = VMAT with double partial arcs. G1 = group 1, G2 = group 2, G3 = group 3.