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. 2020 Jan 21;9:1565. doi: 10.3389/fonc.2019.01565

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Copyright © 2020 Wang, Deng, Dai, Niu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-27a acted as a tumor suppressive role in cSCC. Relative expression of miR-27a was detected in HSC-5 or HSC-1 cells treated with miR-27a mimic (A) or inhibitor (B). Cell proliferation were determined by CCK-8 assays at 24, 48, and 72 h after transfection (C,D). Cell invasions were detected by transwell assays with matrigels (E,F). Magnification: 200×. Each experiment was performed in triplicate and data are presented as mean ± s.d. One-Way ANOVA and Dunnett's Multiple comparison test were used to analyze the data (*P < 0.05, **P < 0.01, ***P < 0.001).