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. 2020 Jan 27;10:1212. doi: 10.1038/s41598-020-58290-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Network of Gene Ontology (GO) molecular functions found enriched between the two pancreatic cancer subtypes. Enrichr was used to obtain enriched GO-terms that were visualised in Cytoscape (refer to the methods section). Each node represents a GO-term with similar nodes clustered together and connected by edges with the number of shared genes between the nodes being represented by the thickness of the edges. The size of each node denotes the gene set size of the represented GO-term. The colour of each node represents the magnitude of the combined enrichment score: red represent enrichment in subtype-1 tumours and blue represents enrichment in subtype-2 tumours. (B) The integrated plot of clinical and molecular features of 45 tumour samples ordered by their SNF clustering positions. From top to bottom panels indicate: patient gender; Age at which a condition or disease was first diagnosed; neoplasm histological grade; SNF subtype of tumour; SMAD4 protein expression level; mTOR protein expression level; significantly mutated genes: TP53, SMAD4 and KRAS gene mutations; SMAD4, CDKN2A and BCL2 gene deep deletion (dark blue) and shallow deletion (pale blue); gene amplification (red) and copy number gain (pink) of multiple genes.