Fig. 4.

A clinically relevant dose of fulvestrant inhibited estrogen dependent tumor growth. a Ovariectomized Nu:J mice bearing HCC1428 breast cancer xenograft tumors were randomized to treatment with vehicle or fulvestrant (25 mg/kg sc qw). *As compared to the vehicle control, significant (p > 0.05) inhibition of tumor growth by fulvestrant was observed for multiple time points. b ER levels present in tumors harvested from mice included in a were analyzed by western blotting of tissue extracts. A significant (p < 0.05) decrease in ER levels was observed for fulvestrant treatment. Primary western blot images are included in Online Resource Fig. 3c