Table 2.
Distribution of PAM50 subtypes by clinical characteristics
| Luminal A % | Luminal B % | Basal-like % | Her2% | Normal % | P | ||
|---|---|---|---|---|---|---|---|
| N | 564 | 284 | 225 | 139 | 41 | ||
| Cancer stage | < 0.0001 | ||||||
| I | 453 | 55.6 | 17.7 | 15.9 | 8.2 | 2.6 | |
| IIA | 432 | 42.4 | 22.9 | 20.1 | 11.1 | 3.5 | |
| IIB | 144 | 34.7 | 26.4 | 20.1 | 15.3 | 3.5 | |
| IIIA | 166 | 37.4 | 31.3 | 13.3 | 13.9 | 4.2 | |
| IIIC | 58 | 29.3 | 25.9 | 25.9 | 15.5 | 3.5 | |
| Tumor grade | < 0.0001 | ||||||
| Well-differentiated | 159 | 80.5 | 12 | 2.5 | 1.3 | 3.8 | |
| Moderately-diff | 496 | 57.3 | 26.6 | 4.8 | 7.9 | 3.4 | |
| Poorly diff | 497 | 17.9 | 23.9 | 37.4 | 18.1 | 2.6 | |
| Unspecified | 101 | 62.4 | 13.9 | 10.9 | 7.9 | 5 | |
| Mean age at diagnosis (SE) | 52.8 (0.4) | 50.8 (0.5) | 48.2 (0.6) | 50.5 (0.8) | 49.6 (1.2) | <0.0001 | |
| Menopausal status at diagnosis | 0.02 | ||||||
| Pre-menopausal | 40.3 | 25 | 19.9 | 10.9 | 3.9 | ||
| Post-menopausal | 49.7 | 20.3 | 16.3 | 11.3 | 2.7 |