Table 3.
Multivariate Cox regression survival analysis of variables (with and without IDH2) predicting outcome in terms of ipsilateral local recurrences in all patients treated by breast conserving surgery in pure ductal carcinoma in situ cohort
| Parameters | Hazard ratio (HR) | 95% confidence interval (CI) | p value | |
|---|---|---|---|---|
| Lower | Upper | |||
| Conventional clinicopathological parameters associated with high-risk DCIS | ||||
| Patient age | 0.3 | 0.1 | 0.5 | 0.0001 |
| DCIS size | 1.6 | 0.9 | 2.7 | 0.055 |
| DCIS nuclear grade | 1.8 | 1.2 | 2.7 | 0.002 |
| Comedo necrosis | 0.6 | 0.4 | 1.1 | 0.096 |
| Margin status | 0.8 | 0.7 | 0.9 | 0.012 |
| Expression of IDH2 and other clinicopathological parameters associated with high-risk DCIS | ||||
| IDH2 expression | 2.0 | 1.1 | 3.9 | 0.034 |
| Patient age | 0.2 | 0.1 | 0.4 | < 0.0001 |
| DCIS size | 1.6 | 0.8 | 3.3 | 0.224 |
| DCIS nuclear grade | 1.3 | 0.8 | 2.4 | 0.315 |
| Comedo necrosis | 1.5 | 0.7 | 3.3 | 0.345 |
| Margin status | 0.8 | 0.7 | 0.9 | 0.039 |
Significant p values are in bold