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. 2020 Jan 27;10:1245. doi: 10.1038/s41598-020-58005-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Graphical representation of fenugreek’s ability to reverse HFD-induced changes in individual intestinal microbiota. The ability of high fat diet to significantly alter the representation of individual taxa was assessed as described in Methods showing that out of 410 Core OTUs, 57 were significantly increased and 90 significantly decreased by HFD. Fenugreek supplementation significantly reversed the effects of HFD on 50 of these OTUs by reducing the representation of 27 HFD-increased OTUs and bolstering the representation of 23 OTUs reduced by HFD.