Table 3.

OTUs that predicts metabolic decline in high fat-fed mice.

Correlation (Pearson) of HFD-Decreased, Fenugreek-Corrected OTU’s to Metrics of Metabolic Function
Individual OTUs Decreased by High Fat Diet (HF) Corrected by FG	Total Chol.	LDL Chol.	HDLChol.	Body Weight	Body Fat	Fasting Glucose	Glucose Tolerance
Firmicutes/Clostridia/Clostridiales/Lachnospiraceae/Clostridium_XlVa/Species1	ns	ns	ns	ns	0.0014	ns	0.0001
Firmicutes/Clostridia/Clostridiales/Lachnospiraceae/Clostridium_XlVa/Species2	ns	ns	ns	0.0027	0.0025	ns	ns
Firmicutes/Clostridia/Clostridiales/Lachnospiraceae/Clostridium_XlVa/Species3	0.0001	0.0034	0.0011	ns	ns	0.0006	0.0001
Firmicutes/Clostridia/Clostridiales/Ruminococcaceae/Flavonifractor	1.2E-05	0.0005	0.0001	1.6E-06	2.1E-06	2.2E-05	1.9E-05
Firmicutes/Erysipelotrichia/Erysipelotrichales/Erysipelotrichaceae/Turicibacter	0.0004	ns	0.0024	ns	ns	ns	0.0015
Firmicutes/Clostridia/Clostridiales/Ruminococcaceae/Oscillibacter	0.0002	ns	1.3E-05	ns	4.0E-05	0.0002	4.2E-05
Firmicutes/Clostridia/Clostridiales/Ruminococcaceae/Intestinimonas	0.0009	0.0021	0.0026	ns	ns	0.0004	0.0017
Firmicutes/Clostridia/Clostridiales/Lachnospiraceae/Acetatifactor/Species 1	ns	ns	ns	ns	ns	ns	0.0012

Individual OTUs in which fenugreek administration reversed high fat diet-induced decreases in representation were correlated against measures of hyperlipidemia. Data are p values of Pearson correlation with total cholesterol (mg/dl), low-density lipoprotein (LDL Chol.; mg/dl), high-density lipoprotein (HDL Chol.; %TC), body weight (grams), body fat (grams), fasting blood glucose (mg/dl), and glucose tolerance (blood glucose levels 40 minutes after oral loading). See Supplementary Table 1 for additional details (log2FC and Pearson r values) on HFD-decreased, fenugreek corrected taxa.