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. 2020 Jan 27;10:1233. doi: 10.1038/s41598-019-56444-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Network reconstruction from IFNγ stimulation experiments. (A) Reconstructed signaling pathway from the IFNγ stimulated time-course experiment. (B) Reconstructed signaling pathway from a time-course experiment that combined stimulation of IFNγ and PI3K inhibition (reconstructed signaling pathways from other inhibition time-course experiments are shown in the Supplement Fig. SI.11.7). For both figures (A,B), the edges with solid lines represent stable undirected relationships between proteins across all time-points and the dashed lines connect protein pairs that are partially correlated only for some time points. (C) Heatmap of the estimated partial correlation using all four available mass-cytometry time-course datasets. All datasets are IFNγ stimulated and three additional experiments are perturbed with inhibitors of PI3K, AMPK and MEK1/2 for validation purposes. The heatmap shows the estimated partial correlation of the union of top 20 protein-pairs selected from different biological experiments.