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. 2020 Jan 27;10(1):9. doi: 10.1038/s41408-020-0276-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The trend of the absolute lymphocyte count after treatment with each regimen. Color-coded arrows indicate treatment regimens given before bortezomib-panobinostat (blue arrows). Orange: HyperCVAD B, yellow: pembrolizumab, green: gemcitabine, vinorelbine, liposomal doxorubicin, red: pralatrexate. A rapid and sustained reduction of the ALC was seen after treatment with the BP regimen. This was accompanied by an improvement in hemoglobin and platelet count (data not shown). PET scan. b The post treatment scan shows an interval significant reduction in size of splenomegaly, measuring 15.6 cm craniocaudally compared with 27.9 cm at initial presentation. c The splenic FDG uptake has normalized in the interim. The previous scan shows heterogeneous increased FDG accumulation indicating disease involvement.