Table 1.
Minimum Inhibitory Concentrations (MIC) of imipenem and/or amoxicillin in combination with relebactam against M. abscessus clinical isolates (including NCTC 13031) and M. abscessus pVV16-blaMab and M abscessus pVV16.
| M. abscessus strain | MIC (mg/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AMX | IMI | REL | AMX (+REL) | IMI (+REL) | REL (+AMX) | REL (+IMI) | AMX (+IMI +REL) | IMI (+AMX+REL) | REL (+AMX +IMI) | |
| NCTC | >128 | 2 | >32 | 64 | 2 | 2 | 1 | 32 | 0.5 | 0.25 |
| DC088 A | >128 | 4 | >32 | 128 | 2 | >32 | 1 | 64 | 1 | 0.5 |
| DC088 B | >128 | 4 | >32 | 32 | 4 | >32 | 2 | 32 | 1 | 0.5 |
| DC088 C | >128 | 8 | >32 | >128 | 4 | >32 | 2 | 32 | 1 | 0.5 |
| DC088 D | >128 | 4 | >32 | >128 | 4 | >32 | 2 | 4 | 2 | 1 |
| DC088 E | >128 | 2 | >32 | 128 | 2 | 16 | 1 | 64 | 1 | 0.5 |
| DC088 Ref | >128 | 4 | >32 | >128 | 2 | >32 | 1 | 64 | 1 | 0.5 |
| 211666 | >128 | 4 | >32 | 128 | 2 | 8 | 1 | 64 | 1 | 0.5 |
| 137071 | >128 | 2 | >32 | 128 | 4 | 16 | 2 | 16 | 2 | 1 |
| 199277 | >128 | 4 | >32 | 64 | 4 | 16 | 2 | 128 | 1 | 0.5 |
| 194891 | 8 | 4 | >32 | 4 | 2 | 0.5 | 1 | 64 | 1 | 0.5 |
| 159544 | >128 | 4 | >32 | 128 | 2 | 1 | 1 | 8 | 1 | 0.5 |
| 186433 | >128 | 2 | >32 | 128 | 4 | 32 | 2 | 128 | 1 | 0.5 |
| 186144 | >128 | 8 | >32 | 128 | 4 | 4 | 2 | 64 | 1 | 0.5 |
| 186154 | >128 | 16 | >32 | >128 | 4 | >32 | 2 | 8 | 4 | 2 |
| 147028 | >128 | 4 | >32 | >128 | 4 | >32 | 2 | 16 | 1 | 0.5 |
| pVV16-blaMab | >128 | 32 | >32 | 128 | 8 | 16 | 4 | 0 | 2 | 4 |
| pVV16 | >128 | 2 | >32 | 32 | 2 | 2 | 1 | 32 | 1 | 0.5 |