Table 1.
PD-L1 expression (TPS) in correlation with patient characteristics.
| TPS | ≥1% | 0 | P- | ≥5% | 0–4 | P- | ≥10% | 0–9 | P- | ≥50% | 0–4 | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PD-L1 status | positive | negative | positive | negative | positive | negative | positive | negative | P- | |||
| Age, median (years) | 75.0 | 73.0 | 0.468 | 73.0 | 74.0 | 0.442 | 74.0 | 73.5 | 0.901 | 71.0 | 73.9 | 0.221 |
| Sex | ||||||||||||
| female | 6 (14.0) | 7 (17.5) | 0.766 | 6 (19.4) | 7 (13.5)) | 0.539 | 4 (16.0) | 9 (15.5) | 1.000 | 2 (14.3) | 11 (15.9) | 1.000 |
| male | 37(86.0) | 33 (82.5) | 25 (80.6) | 45 (86.5) | 21 (84.0) | 49 (84.5) | 12 (17.1) | 58 (84.1) | ||||
| Smoking status | ||||||||||||
| never | 0 (0.0) | 1 (2.5) | 0 (0.0) | 1 (1.9) | 0 (0.0) | 1 (1.7) | 0 (0.0) | 1 (1.4) | ||||
| former | 18 (41.9) | 21 (52.5) | 0.322 | 15 (48.4) | 24 (46.2) | 0.735 | 10 (40.0) | 29 (50.0) | 0.531 | 5 (35.7) | 34 (49.3) | 0.559 |
| current | 25 (58.1) | 18 (41.9) | 16 (51.6) | 27 (51.9) | 15 (60.0) | 28 (48.3) | 9 (64.3) | 34 (49.3) | ||||
| Brinkman index, median (pack-year) | 56.0 | 53.0 | 0.369 | 56.0 | 53.8 | 0.197 | 60.0 | 51.0 | 0.033 | 61.3 | 52.0 | 0.040 |
| Cell differentiation | ||||||||||||
| well | 5 (11.6) | 6 (15.0) | 3 (9.7) | 8 (15.4) | 3 (12.0) | 8 (13.8) | 2 (18.2) | 9 (13.0) | ||||
| moderately | 29 (67.4) | 25 (62.5) | 0.870 | 22 (71.0) | 32 (61.5) | 0.648 | 18 (72.0) | 36 (62.1) | 0.657 | 8 (57.1) | 46 (66.7) | 0.762 |
| poorly | 9 (20.9) | 9 (22.5) | 6 (19.4) | 12 (23.1) | 4 (16.0) | 14 (24.1) | 4 (28.6) | 14 (20.3) | ||||
| Pathologic stage | ||||||||||||
| IA | 22 (51.2) | 19 (47.5) | 0.827 | 15 (48.4) | 26 (50.0) | 1.000 | 13 (52.0) | 28 (48.3) | 0.814 | 7 (50.0) | 34 (49.3) | 1.000 |
| IB | 21 (48.8) | 21 (52.5) | 16 (51.6) | 26 (50.0) | 12 (48.0) | 30 (51.7) | 7 (50.0) | 35 (50.7) | ||||
| Mode of lung resection | ||||||||||||
| Sub-lobar resection | 9 (20.9) | 9 (22.5) | 1.000 | 8 (25.8) | 10 (19.2) | 0.584 | 6 (24.0) | 12 (20.7) | 0.776 | 3 (21.4) | 15 (21.7) | 1.000 |
| Lobectomy | 34 (79.1) | 31 (77.5) | 23 (74.2) | 42 (80.8) | 19 (76.0) | 46 (79.3) | 11 (78.6) | 54 (78.3) | ||||
| Adjuvant chemotherapy | ||||||||||||
| Performed | 4 (9.3) | 7 (17.5) | 0.340 | 2 (6.5) | 9 (17.3) | 0.197 | 1 (4.0) | 10 (17.2) | 0.160 | 0 (0.0) | 11 (15.9) | 0.197 |
| NLR, median | 2.41 | 2.14 | 0.397 | 2.26 | 2.20 | 0.932 | 2.21 | 2.21 | 0.812 | 2.29 | 2.21 | 0.942 |
| low | 18 (41.9) | 23 (57.5) | 0.190 | 14 (45.2) | 27 (51.9) | 0.651 | 12 (48.0) | 29 (50.0) | 1.000 | 7 (50.0) | 34 (49.3) | 1.000 |
| high | 25 (59.5) | 17 (42.5) | 17 (54.8) | 25 (48.1) | 13 (52.0) | 29 (50.0) | 7 (50.0) | 35 (50.7) | ||||
NLR, neutrophil to lymphocyte ratio; Data represented as absolute counts (%) or median.