Table 2.

Univariable and Multivariable Cox model of prognostic factors for recurrence-free survival and overall survival.

	Recurrence-free survival						Overall survival
	Univariable analysis			Multivariable analysis			Univariable analysis			Multivariable analysis
	HR	95% CI	P-	HR	95% CI	P-	HR	95%CI	P-	HR	95%CI	P-
Age (per 1-year increase)	1.016	0.972–1.063	0.476				1.031	0.981–1.083	0.229
Sex, female (vs male)	0.791	0.307–2.037	0.791				0.777	0.272–2.218	0.637
Smoking status, current smoker (vs never smoker)	1.049	0.543–2.027	0.887				1.058	0.526–2.129	0.874
Pathologic stage IB (vs IA)	0.940	0.488–1.814	0.855				1.040	0.518–2.089	0.911
Mode of lung resection, sub-lobar resection (vs lobectomy)	1.967	0.936–4.134	0.074				1.456	0.622–3.405	0.386
Adjuvant chemotherapy, performed (vs not performed)	0.397	0.121–1.299	0.127				0.450	0.137–1.483	0.189
NLR-low/PD-L1(-) vs others
PD-L1(-): TPS = 0	0.237	0.083–0.674	0.007	0.239	0.082–0.693	0.008	0.260	0.091–0.745	0.012	0.276	0.094–0.808	0.019
PD-L1(-): TPS, 0–4	0.358	0.155–0.827	0.016	0.365	0.154–0.855	0.022	0.401	0.171–0.940	0.036	0.426	0.178–0.969	0.045
PD-L1(-): TPS, 0–9	0.396	0.179–0.878	0.023	0.392	0.173–0.888	0.025	0.378	0.161–0.883	0.025	0.390	0.164–0.928	0.033
PD-L1(-): TPS, 0–49	0.430	0.206–0.899	0.025	0.437	0.206–0.929	0.031	0.349	0.156–0.784	0.011	0.359	0.157–0.821	0.015

HR, hazard ratio; CI, confidence interval.

NLR, neutrophil-to-lymphocyte ratio.

TPS, tumor proportion score.