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. 2020 Jan 21;9:1549. doi: 10.3389/fonc.2019.01549

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Copyright © 2020 Abildgaard, Do Canto, Steffensen and Rogatto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The lncRNAs involved in taxane resistance in OC. Aberrant expression of the lncRNAs depicted on top (green circles) leads to taxane resistance through three main mechanisms: cell cycle regulation, upregulation of drug transporters leading to efflux of the drug, or epithelial-mesenchymal transition. The molecular mechanisms linking the lncRNAs to these resistance mechanisms involve interactions with miRNAs (light blue) and regulation of transcription factors or signaling pathways (black), as illustrated above.