Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 21;10:3086. doi: 10.3389/fimmu.2019.03086

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Levin, Evans, Bort, Rickel, Lewis, Wu, Hoover, MacNeil, La, Wolfson, Rixon, Dillon, Kornacker, Swanson and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

ICOSL mutations identified at predicted interaction sites of homologous B7/CD28 family members. (A) Interaction of human CD80 with human CTLA4 as deduced from the crystal structure of CD80 extracellular domain dimer complexed with single extracellular domain of CTLA4 per CD80 monomer (PDB ID: 1I8L). (B) Homology model of human ICOSL extracellular domain based on CD80/CTLA4 complex. ICOSL residues predicted to be located within 5 angstroms of ICOS are colored cyan and marked by an asterisk. ICOSL residues frequently mutated through yeast library selection are colored purple and indicated in bold. Residues are split between front and back view of ICOSL dimer (rotated 180°) to maximize visibility in figure.