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. 2020 Jan 21;10:3086. doi: 10.3389/fimmu.2019.03086

Figure 7.

Figure 7

ICOSL vIgD-Fc expressed on the surface of cells deliver a costimulatory T cell signal. Cell Trace Far Red labeled human T cells were cocultured with K562 cells expressing the indicated versions of ICOSL vIgD-Fc and stimulated with a range of soluble CD3 antibody concentrations. Cells were harvested after 72 h and proliferation of (A) CD4 and (B) CD8 human T cells is reported as percent of cells divided vs. anti-CD3 concentration. Each point represents the mean of triplicate wells with error bars showing standard deviation (s.d.).