Fig. 3.

Processing and presentation of CIGB-814 by dendritic cells to T-lymphocytes in the gut or LNs could induce the expansion of Treg. These activated cells migrate to inflammation site (joints) and could cross-recognize wild-type epitope from HSP60, where it is highly expressed due to the inflammation process. This new contact with this autoantigen may induce potent immuno-regulatory effect, attenuating autoreactive T cells responsible of RA pathogenesis and inhibiting inflammatory cytokines