Figure 3. Screen for compounds that selectively kill CIN cells reveals several candidates.

(A, B, C, D) Growth curves of control and Mad2^cKD RPE1 cells were analyzed during the first half (day 1–4) (A, B) and the second half (day 5–8) of the screen (C, D). (A, B, C, D) The non-CIN over CIN ratios for AUC (A, C) and slope analysis (B, D) were plotted per drug against the P-value. All drugs with log of difference >|0.15|, and P-value < 0.05 are plotted; drugs with P-values < 0.05 after Bonferroni correction are labeled blue.