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. 2020 Jan 21;10:3134. doi: 10.3389/fimmu.2019.03134

Figure 5.

Figure 5

Pulmonary immune cells, cytokines and total serum IgE in female offspring from vehicle and CORT-treated dams. (A) Schematic representation of dam and offspring treatments. Pregnant females received corticosterone (CORT) or vehicle in g water at E12.5 until the end of pregnancy. Female offspring from CORT and vehicle treated dams were treated with saline or HDM consisting of 135 μg of the major allergen Der p 1. (B) Immune cells were quantified, total number of eosinophils, neutrophils, lymphocytes, and alveolar macrophages in BAL of female offspring from vehicle or CORT-treated dams, treated with HDM or saline (n = 5–9). (C) Cytokine and chemokine concentrations in BALF were compared between HDM-treated female offspring from vehicle and CORT-treated dams. Interleukin-4, IL-5, IL-13, KC, and MCP-1 concentrations are reported as pg/mL in BALF. (D) Total IgE in serum of female offspring treated with saline (circle) and HDM (triangle), with concentrations reported as ng/mL (n = 4). * p < 0.0001.